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副作用最多见于临床试验中的味觉改变或味觉障碍（比如口中含有苦味或金属味）通常这种味觉改变是短暂的，能持续至该药物的半衰期过期。
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Skipped DOSE: Acquire your dose at or near bedtime. In the event you skip a dose, usually do not acquire if close to the time for another dose. Instead, skip the missed dose and resume your normal dosing routine. Never "double-up" the dose to capture up.
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